Ephesians 6:19-21

The text says,

and also for me, that words may be given to me in opening my mouth boldly to
proclaim the mystery of the gospel, for which I am an ambassador in chains, that
I may declare it boldly, as I ought to speak. So that you also may know how I am
and what I am doing, Tychicus the beloved brother and faithful minister in the
Lord will tell you everything. (Ephesians 6:19-21)

The first thing one should note here is that the Apostle does not ask for prayers for his safety, or for God to save his life from the Romans. Instead, he asks his spiritual children to pray that he would boldly preach the Gospel. I think there are two lessons we can learn here. First, we like the Ephesians should pray that our spiritual leaders would serve to advance the Gospel of Christ. It is very easy for us to fall into the trap of assuming that our pastors' seminary degrees give them an uncanny ability to preach the Gospel. But eloquent speech does not convince a person to come to Christ. Our words are not useful unless the Spirit is at work. Even Moses, who was Israel's greatest prophet, acknowledged his inability to preach the Gospel apart from God:

But Moses said to the LORD, "Oh, my Lord, I am not eloquent, either in the past
or since you have spoken to your servant, but I am slow of speech and of
tongue." Then the LORD said to him, "Who has made man's mouth? Who makes him mute, or deaf, or seeing, or blind? Is it not I, the LORD? Now therefore go, and
I will be with your mouth and teach you what you shall speak." (Exodus 4:10-12)

But we should remember that God promises to give us words to preach. Therefore, it is very important that we pray for our leaders, so that God would work in their ministry.

Secondly, we should desire to spread the Gospel even at the cost of our personal convenience. Missionaries, for example, endure quite a bit of inconvenience, by uprooting themselves from their home communities and living radically different lifestyles. Yet they do so for the sake of the Gospel. Now, we are not all called to be missionaries. However, I think we are all called to live radically for the spread of the Gospel.

Let's also note that Paul saw an importance in informing the churches about his conditon, so much so that he sent Tychicus to personally deliver the epistle. His purpose is mentioned in the next verse:

I have sent him to you for this very purpose, that you may know how we are,
and that he may encourage your hearts. (Ephesians 6:22)

Personally, I often have the tendancy to not pay attention when people in the church report on God's work in Bethlehem's missions. But on the contrary, God's work through missionaries ought to encourage us. Therefore, let us also pray that God would give us a heart for missions, even to those of us who aren't specifically called to be missionaries.